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Meanwhile, studies in Drosophila melanogaster reveal that enhancing the expression of the catalytic or modulatory subunits of GCL (glutamate-cysteine ligase) can lead to an increase in glutathione levels and promote a longer lifespan [132]

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doi: 10.3389/fphar.2025.1600484 Received 26 March 2025 Accepted 21 August 2025 Published 10 September 2025 Volume 16 - 2025 Edited by Ilkay Erdogan Orhan, Lokman Hekim University, Trkiye Reviewed by Galal Metwally, Zagazig University, Egypt Fatimah Yousef, King Abdulaziz University, Saudi Arabia Olamide Fasakin, Federal University of Technology, Nigeria Updates Copyright 2025 Al Zaabi, Al Suleimani, Ali, Ali and Al Maskari

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